ForecastedFederal grantOpen to for-profit businessesFOR-AT-25-007

Assessing the Feasibility of Incorporating Mechanisms in Multisite Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration

National Institutes of HealthCloses Oct 15, 2026(2 days left)

Does this fit your business?

This is a forecasted NIH/NCCIH R33 grant for multisite feasibility studies of mind and body interventions like meditation, yoga, acupuncture, and music aimed at whole person health restoration. It is for research teams that can run clinical trials across at least two geographically distinct sites and measure outcomes using the Whole Person Health Index. Retail shops, restaurants, construction firms, farms, and any business without clinical trial research capability should not bother applying.

Best for
Small businesses with clinical trial research capability, Nonprofits running mind-body or integrative health studies, Universities and academic medical centers, Multidisciplinary teams with multisite trial experience
Not for
Businesses outside health research with no clinical trial capability, Organizations unable to operate across multiple sites, Applicants seeking funding for services or operations rather than research
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
66
Good Match
Education & TrainingLimit: Closes in 27 days
52
Possible Match
Environment & ConservationLimit: Closes in 27 days
51
Possible Match
Energy & Clean TechLimit: Closes in 27 days
49
Possible Match
Social Services & NonprofitLimit: Closes in 27 days
48
Possible Match
Arts & CultureLimit: Closes in 27 days
47
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Technology & SoftwareLimit: Closes in 27 days
47
Possible Match
Housing & Real EstateLimit: Closes in 27 days
46
Possible Match
ManufacturingLimit: Closes in 27 days
43
Possible Match
Finance & BankingLimit: Closes in 27 days
42
Possible Match
Food & BeverageLimit: Closes in 27 days
42
Possible Match
Retail & E-CommerceLimit: Closes in 27 days
41
Possible Match
Transportation & LogisticsLimit: Closes in 27 days
40
Possible Match
Agriculture & FarmingLimit: Closes in 27 days
39
Possible Match
Construction & InfrastructureLimit: Closes in 27 days
38
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Clinical trials, Feasibility studies, Multisite studies, Mechanistic research
Who can apply
Small businesses, For-profit companies, Nonprofits, Colleges and universities, State and local governments, Tribal governments and organizations, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is October 15, 2026. Note that this is a forecasted opportunity, so applications are not being solicited yet.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations, 501(c)(3) nonprofits, private and public institutions of higher education, independent school districts, state and county governments, public housing authorities, and federally and non-federally recognized tribal organizations. Multidisciplinary teams with experience in complementary and integrative health, clinical trial design, and mechanistic research are particularly encouraged to apply.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. However, small businesses and for-profit organizations are listed as eligible applicant types, so a single-member LLC structured as a small business may qualify. Check the forthcoming full announcement for details.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status with the IRS, other than institutions of higher education, are listed as eligible applicants.

Summary

NIH/NCCIH forecasted R33 grant for multisite feasibility studies of mind and body interventions (meditation, yoga, acupuncture, music) on whole person health restoration. Eligible: small businesses, for-profits, nonprofits, higher ed, state/county governments, tribal orgs, school districts, housing authorities. Funds clinical trial feasibility research across at least two sites.

About this grant

The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Notice of Funding Opportunity (NOFO) to support multi-site feasibility studies of mind and body interventions (e.g., meditation, yoga, acupuncture, music, or multicomponent interventions) on whole person health restoration. The goal of this NOFO is to establish foundational work necessary to inform and enable future large-scale clinical efficacy and effectiveness trials of mind and body interventions on whole person health restoration, as well as investigation of the potential mediating effects of mind and body interventions on whole person health restoration by established or well-studied mechanisms underlying emotional well-being (EWB). Studies proposed under this NOFO must be conducted across at least two geographically distinct sites to enhance generalizability and reproducibility. Key expectations to achieve the NOFO goal include: 1) demonstrating that the mind and body intervention can be delivered with fidelity across sites; 2) demonstrating reproducibility and rigor in engaging targeted mechanisms of EWB by the mind and body intervention across sites; 3) assessing feasibility of participant recruitment and retention, as well as randomization; 4) assessing feasibility of collecting comprehensive clinical (whole person health restoration) and mechanistic (EWB) data across sites; and 5) exploring correlations between changes in mechanistic targets and clinical outcome measurements pulled across sites. Applicants are required to use the Whole Person Health Index and may also use one or more of its individual components as the clinical outcome measure of whole person health restoration. Additional clinical outcome measures are allowable based on clinical relevance. This NOFO will complement a different NCCIH funding opportunity (PAR-25-449) supporting mechanistic clinical trials by emphasizing the critical step of feasibility testing in real-world and multisite settings. Multidisciplinary teams with experience in complementary and integrative health, clinical trial design, and mechanistic research are particularly encouraged to consider applying. Applications are not being solicited at this time. This Notice is being issued to provide potential applicants ample time to develop strong, collaborative, and responsive project plans. This anticipated NOFO will utilize the R33 Clinical Trial Required activity code. Further details will be provided in the forthcoming announcement.

Who can apply

The listing does not include detailed eligibility text. Check the official listing before you apply.

Topics and uses of funds

Topics

  • Health
  • Research
  • Clinical trials
  • Complementary integrative health
  • Behavioral health

Program contact

Jennifer N. Baumgartner, Ph.D. National Center for Complementary and Integrative Health (NCCIH)jennifer.baumgartner@nih.gov301-402-4084

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