OpenFederal grantOpen to for-profit businessesPAR-27-045

HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)

National Institutes of HealthCloses Oct 30, 2026(17 days left)

Does this fit your business?

This is an NIH clinical research grant for studying the biological mechanisms of joint pain and testing non-drug treatments, not a business grant. It fits research organizations with clinical trial capability; most small businesses outside healthcare and biotech research should not bother applying.

Best for
Healthcare and biotech research organizations, Universities and academic medical centers, Nonprofits with clinical research capacity, Small businesses doing biomedical R&D
Not for
Retail, finance, transportation, or other businesses outside biomedical research, Foreign organizations or U.S. organizations with foreign components, Organizations without clinical research capability
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
77
Strong Match
Arts & CultureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
ManufacturingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
52
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
51
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
51
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
50
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
50
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
49
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is October 30, 2026.
Who can apply for this grant?
Eligible applicants include state, local, county, and city governments, tribal governments and tribal organizations, public and private institutions of higher education, independent school districts, public housing authorities, nonprofits with or without 501(c)(3) status, for-profit organizations other than small businesses, and small businesses. Foreign organizations and foreign components of U.S. organizations are not eligible.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligibility list names small businesses and for-profit organizations generally, but sole proprietors and single-member LLCs are not specifically addressed, so check Section III of the NOFO.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH HEAL Initiative phased R61/R33 mechanistic clinical research program to identify and validate multi-tissue biological mechanisms underlying joint pain and then test non-pharmacologic or multimodal interventions targeting those mechanisms. Eligible applicants include states, local and tribal governments, higher education institutions, nonprofits, public housing authorities, school districts,for

About this grant

The NIH Helping to End Addiction Long-term ® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.

Topics and uses of funds

Topics

  • Health
  • Science

Program contact

National Institutes of HealthNCCIHDERFunding@nih.gov301-402-2541

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