OpenFederal grantOpen to for-profit businessesPA-23-317

Competing Revisions to Existing NIH Single Project Research Grants and Cooperative Agreements (Clinical Trial Optional)

National Institutes of HealthCloses Nov 24, 2026(42 days left)

Does this fit your business?

This is not a grant for starting research; it is a competitive revision that expands an NIH-funded project you or your institution already holds. If your organization does not currently have an NIH award responding to an Institute's Notice of Special Interest, do not bother applying. Small businesses and for-profits can apply, but only as NIH recipients expanding existing work.

Best for
Small businesses with an existing NIH-funded research award, Universities and research institutions expanding a current NIH project, Nonprofits already holding an NIH grant, Tribal and government entities with an active NIH award
Not for
Businesses with no existing NIH-funded award, Retail, finance, or housing ventures, Organizations starting research from scratch
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
86
Strong Match
Technology & SoftwareMatches your industry (tech)
75
Strong Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, Expansion
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
November 24, 2026.
Who can apply for this grant?
Only current NIH award recipients may apply: governments, federally recognized tribes, nonprofits, higher-education institutions, small businesses, other for-profits, and certain other entities such as faith-based and community organizations. Applications must respond to a Notice of Special Interest published by an NIH Institute or Center.
Can a sole proprietor or single-member LLC apply?
The facts do not say. Small businesses are listed as eligible, but the notice does not specify whether sole proprietors or single-member LLCs qualify.
Can a nonprofit apply?
Yes. Nonprofits with and without 501(c)(3) status are eligible, but only if they already hold an NIH award and respond to a published Notice of Special Interest.

Summary

NIH competitive revision supplements to expand existing NIH-funded research projects/programs, per Institute-specific Notices of Special Interest. Eligible: governments, tribes, nonprofits, higher-ed institutions, small businesses, other for-profits, faith/community organizations, and some foreign entities. Funds support expansion of the parent award's scope.

About this grant

The National Institutes of Health (NIH) hereby notifies NIH award recipients that funds may be available for revision applications to support the expansion of existing projects and/or programs within the awarding IC identified in the competitive revision Notice of Special Interest (NOSI). Applications for Revisions will be evaluated for scientific and technical merit by (an) appropriate Scientific Review Group(s), in accordance with NIH peer review policy and procedures, using the stated review criteria. Only applications submitted in response to a NOSI published by an NIH Institute or Center will be allowed to apply to this NOFO.

Who can apply

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

Topics and uses of funds

Topics

  • Health
  • Science
  • Research

Program contact

National Institutes of Healthgrantsinfo@nih.gov301-402-2541

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