ForecastedFederal grantOpen to for-profit businessesRFA-ES-27-009

Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)

National Institutes of HealthCloses Jan 5, 2027(84 days left)$100,000 – $500,000

Does this fit your business?

This is an NIH research grant for mechanistic studies of how metals affect human health — transport, placental crossing, immune and CNS effects. It is for organizations that can run serious scientific research, not for businesses looking for general operating money. If your company is not doing metals toxicology or adjacent biomedical research, do not apply.

Best for
Universities and academic research labs, Nonprofits with research programs, Small businesses doing toxicology or biotech R&D, Tribal and government research bodies
Not for
Retail, finance, or arts organizations with no research angle, Anyone wanting to run a clinical trial, Businesses looking for working capital or product commercialization
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, clinical)
69
Good Match
Education & TrainingMatches your industry (stem)
60
Good Match
Environment & ConservationDeadline is more than 60 days away
59
Good Match
Transportation & LogisticsMatches your industry (transport)
59
Good Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
53
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
51
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
50
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
50
Possible Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
49
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
47
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
47
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
47
Possible Match
Technology & SoftwareLimit: Nothing in this notice points to technology & software
47
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
45
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
$100,000 – $500,000

Questions about this grant

When is the application deadline?
January 5, 2027.
How much funding can an applicant receive?
Awards range from $100,000 to $500,000. NIH expects to make about 20 awards from a total program budget of $15,000,000.
Who can apply for this grant?
Universities, independent school districts, state/local/county governments, tribes and tribal organizations, nonprofits with or without 501(c)(3) status, and for-profit organizations including small businesses may apply. Clinical trials are not allowed under this program.
Can a sole proprietor or single-member LLC apply?
The facts do not say. The eligibility list covers small businesses and for-profit organizations generally, but it does not specifically name sole proprietors or single-member LLCs, so you would need to check with NIH directly.
Can a nonprofit apply?
Yes. Both 501(c)(3) nonprofits and nonprofits without 501(c)(3) status may apply, as long as they are not institutions of higher education (those are covered under a separate category).

Summary

NIH (NIEHS) research grants for mechanistic studies of how metals and metal-containing compounds alter biological processes relevant to human health, including transport, placental crossing, immune and CNS effects. Open to universities, nonprofits, governments, tribes, and for-profit organizations including small businesses; clinical trials not allowed.

About this grant

The purpose of this funding opportunity is to support mechanistic research to understand how exposure to metals and metal-containing compounds alters biological processes relevant to human health. Of particular interest are studies that elucidate the absorption, distribution, transport, cellular trafficking, biological interactions, and mechanisms of action of metals, including mechanisms through which metals may alter immune homeostasis, cross the placental barrier, or gain access to and affect the central nervous system. Studies may employ experimental models, new approach methodologies, computational approaches, or leverage human biospecimens where these approaches are used to address defined mechanistic hypotheses.

Who can apply

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;

Topics and uses of funds

Topics

  • Health
  • Science
  • Environment

Program contact

NOFO.information@niehs.nih.govNOFO.information@niehs.nih.govPlease contact via email.

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