OpenFederal grantOpen to for-profit businessesDE-FOA-0003612

The Genesis Mission: Transforming Science and Energy with AI

Office of ScienceCloses Dec 17, 2026(65 days left)$500,000 – $16,000,000

Does this fit your business?

This is a DOE Office of Science program funding interdisciplinary teams to build novel AI models and frameworks for energy, environmental, and nuclear challenges, with topic areas spanning advanced manufacturing, biotech, nuclear, quantum, semiconductors, and energy. Awards run from $500,000 to $16 million and cost sharing is required, so this is for serious R&D players, not casual applicants. Retail, finance, and housing businesses with no AI or energy research angle should not bother.

Best for
Technology and software companies building AI models or R&D workflows, Energy and clean tech firms working on energy, nuclear, or critical materials challenges, Environmental and conservation organizations addressing environmental challenges through science and technology, Interdisciplinary teams able to partner with National Labs, industry, or academia
Not for
Retail and e-commerce businesses, Finance and banking firms, Housing and real estate companies, Organizations unable to meet cost sharing requirements
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechMatches your industry (energy)
89
Strong Match
Technology & SoftwareMatches your industry (technology, tech, innovation)
89
Strong Match
Environment & ConservationMatches your industry (environment)
87
Strong Match
ManufacturingMatches your industry (manufacturing)
73
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Construction & InfrastructureLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Healthcare & BiotechLimit: Nothing in this notice points to healthcare & biotech
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
Research, R&D, Technical assistance
Who can apply
Small businesses, For-profit companies, Nonprofits, Individuals, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)
Award range
$500,000 – $16,000,000

Questions about this grant

When is the application deadline?
The application deadline is December 17, 2026. The opportunity was posted on March 17, 2026.
How much funding can an applicant receive?
Awards range from $500,000 to $16,000,000, with total program funding of $293,760,000. Cost sharing is required.
Who can apply for this grant?
Any type of entity may apply, including small businesses, for-profit companies, nonprofits, individuals, governments, tribal entities, and higher education institutions. Teams are encouraged to leverage DOE/NNSA, National Laboratories, industry, and academia resources.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. The eligibility is listed as unrestricted, meaning any type of entity may apply, and individuals are listed as an eligible applicant type.
Can a nonprofit apply?
Yes, nonprofits may apply. The program is open to any type of entity, and nonprofits are explicitly listed among the applicant types that may apply.

Summary

DOE Office of Science funding for interdisciplinary teams to develop novel AI models and frameworks addressing national science and technology challenges in energy, environmental, and nuclear areas. Any type of entity may apply; teams encouraged to leverage DOE/NNSA, National Labs, industry, and academia resources. Cost sharing required.

About this grant

The DOE Office of Science (SC), Office of Critical Minerals and Energy Innovation (CMEI), Office of Environmental Management (EM), Office of Nuclear Energy (NE), Office of Electricity (OE), and Hydrocarbons and Geothermal Office (HGEO) hereby announce interest in receiving applications from interdisciplinary teams addressing the Genesis Mission National Science and Technology Challenges to accelerate scientific discovery and research and development (R&D) workflows using novel artificial intelligence (AI) models and frameworks. By achieving AI advantage, these teams will advance the DOE's mission and ensure America’s security and prosperity by addressing energy, environmental, and nuclear challenges through science and technology. Teams are encouraged to leverage the extensive scientific and data resources of the DOE/National Nuclear Security Administration (NNSA), the National Laboratories, U.S. industry, and academia. The resulting AI models and workflows, if successful, may be integrated into the American Science Cloud.

DOE is soliciting new FY26 Phase I small team and Phase II large team applications in the following topic areas: advanced manufacturing, biotechnology, critical materials, nuclear fission, nuclear fusion, quantum information science, semiconductors and microelectronics, discovery science, and energy (see specific focus areas in Section III Program Descriptions).

In addition, this RFA will remain available to allow the recipients of FY26 Phase I awards to apply for larger team Phase II awards. In a few weeks, DOE plans to amend the RFA to clarify the LOI and application guidelines for FY26 Phase II awards. In FY27, DOE plans to amend the RFA or to issue an alternative funding opportunity to update the topic and focus areas to allow a second competition of Phase I small team applications and Phase II large team applications.

Who can apply

The listing does not include detailed eligibility text. Check the official listing before you apply.

Topics and uses of funds

Topics

  • Science
  • Energy
  • Technology
  • Artificial intelligence
  • Advanced manufacturing

Program contact

Michael S Zarkin Grants Management SpecialistGenesisMissionNOFO@science.doe.gov301-903-4946

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