OpenFederal grantOpen to for-profit businessesRFA-RM-27-013

Model-to-Clinic (M2C) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (UG3/UH3, Clinical Trial Optional)

National Institutes of HealthCloses Oct 19, 2026(6 days left)

Does this fit your business?

This is an NIH research and development program for teams moving AI-based clinical decision support tools — built on medical imaging combined with other health data, delivered as Software as a Medical Device — from prototype toward real clinical use in precision medicine. If you are not already developing image-centered AI software for clinical care, do not bother applying. About 8 awards are expected and no cost sharing is required.

Best for
Small businesses and for-profits building AI clinical decision support software, Universities and academic medical research teams, Nonprofits working on precision medicine or health AI, State, local, and tribal government health or research programs
Not for
Businesses with no connection to healthcare, medical imaging, or clinical AI, Organizations seeking funding for unrelated products or general operations
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, medical, clinical)
93
Strong Match
Technology & SoftwareMatches your industry (software)
72
Good Match
Education & TrainingMatches your industry (training)
71
Good Match
Agriculture & FarmingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Nothing in this notice points to finance & banking
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
ManufacturingLimit: Nothing in this notice points to manufacturing
54
Possible Match
Retail & E-CommerceLimit: Nothing in this notice points to retail & e-commerce
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
51
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research, Technical assistance
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is October 19, 2026. The opportunity was posted on June 30, 2026.
Who can apply for this grant?
Eligible applicants include small businesses, other for-profit organizations, nonprofits with or without 501(c)(3) status, public and private institutions of higher education, state, county, city, and special district governments, independent school districts, public housing authorities, and Native American tribal governments and organizations. Foreign organizations and foreign components of U.S. organizations are also eligible. Check Section III of the NOFO for full eligibility details.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses and for-profit organizations other than small businesses are listed as eligible, so a single-member LLC may qualify depending on its structure, but you should confirm in Section III of the NOFO.
Can a nonprofit apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (other than institutions of higher education) are both listed as eligible applicants.

Summary

NIH program to translate AI-enabled, image-centered multimodal clinical decision support tools (Software as a Medical Device) from prototype testing toward clinical use in precision medicine. Open to small businesses, other for-profits, nonprofits, universities, and state/local/tribal governments; foreign entities allowed.

About this grant

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.The purpose of this NOFO is to catalyze the translation of Artificial Intelligence (AI)-enabled, image-centered, multimodal CDS tools, developed as Software as a Medical Device, from training and testing of prototypes towards clinical applications that address unmet health challenges in precision medicine. These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Technology
  • Science

Program contact

National Institutes of HealthODPRIMED-AI@od.nih.gov301-402-2541

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