OpenFederal grantOpen to for-profit businessesRFA-RM-27-012

PRIMED-AI: Data-to-Model Academic-Industrial Partnerships (D2M-AIP) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (UG3/UH3 Clinical Trial Optional)

National Institutes of HealthCloses Oct 19, 2026(6 days left)

Does this fit your business?

This NIH program funds academic-industrial partnerships to develop and test AI-enabled, image-centered clinical decision support tools built as Software as a Medical Device, integrating imaging with other health data to improve patient outcomes. It is for healthcare, biotech, and software organizations that can partner with academic institutions and have the technical capacity to build clinical AI tools. Construction, retail, and finance businesses with no connection to medical imaging or AI are

Best for
Academic-industrial partnerships developing AI clinical decision support tools, Small businesses and for-profits building Software as a Medical Device, Healthcare and biotech organizations integrating imaging with multimodal health data, Institutions of higher education partnering with industry on precision medicine AI
Not for
Businesses with no connection to healthcare, medical imaging, or clinical AI, Organizations unable to form an academic-industrial partnership, Applicants seeking funding for construction, retail, or finance projects
Estimated fit by industry, best first
IndustryEstimated fit
Healthcare & BiotechMatches your industry (health, medical, clinical)
90
Strong Match
Technology & SoftwareMatches your industry (software)
72
Good Match
ManufacturingMatches your industry (industrial)
66
Good Match
Agriculture & FarmingLimit: Nothing in this notice points to agriculture & farming
54
Possible Match
Arts & CultureLimit: Nothing in this notice points to arts & culture
54
Possible Match
Education & TrainingLimit: Nothing in this notice points to education & training
54
Possible Match
Show all 15 industries
Estimated fit by industry, best first
IndustryEstimated fit
Energy & Clean TechLimit: Nothing in this notice points to energy & clean tech
54
Possible Match
Environment & ConservationLimit: Nothing in this notice points to environment & conservation
54
Possible Match
Finance & BankingLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Food & BeverageLimit: Nothing in this notice points to food & beverage
54
Possible Match
Housing & Real EstateLimit: Nothing in this notice points to housing & real estate
54
Possible Match
Retail & E-CommerceLimit: Not clearly about your industry or what you need funding for; check the…
54
Possible Match
Social Services & NonprofitLimit: Nothing in this notice points to social services & nonprofit
54
Possible Match
Transportation & LogisticsLimit: Nothing in this notice points to transportation & logistics
54
Possible Match
Construction & InfrastructureLimit: Nothing in this notice points to construction & infrastructure
51
Possible Match

These are our matcher’s estimates for a typical business in each industry. A real match depends on your size, your state and what you need the money for — check your own fit.

What this funds

Money can be used for
R&D, Research
Who can apply
Small businesses, For-profit companies, Nonprofits, State and local governments, Tribal governments and organizations, Colleges and universities, Other applicants (see eligibility)

Questions about this grant

When is the application deadline?
The application deadline is 2026-10-19.
Who can apply for this grant?
Eligible applicants include small businesses, for-profit organizations other than small businesses, nonprofits with and without 501(c)(3) status, private and public institutions of higher education, independent school districts, state governments, county and city governments, special district governments, public housing authorities, federally recognized tribal governments, tribal organizations, and others as defined in the NOFO. Foreign organizations and foreign components of U.S. organizations are also eligible to apply.
Can a sole proprietor or single-member LLC apply?
The facts do not specifically address sole proprietors or single-member LLCs. Small businesses are eligible, so a single-member LLC that qualifies as a small business may be able to apply, but you should check Section III. Eligibility Information in the NOFO to confirm.
Can a nonprofit apply?
Yes. Nonprofits that have 501(c)(3) status with the IRS, other than institutions of higher education, and nonprofits that do not have 501(c)(3) status with the IRS, other than institutions of higher education, are both listed as eligible applicants.

Summary

Academic-industrial partnerships (including small businesses and for-profits) can apply to develop and test AI-enabled, image-centered multimodal clinical decision support tools (Software as a Medical Device) that integrate imaging with other health data to improve patient outcomes across a wide range of conditions.

About this grant

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this Notice of Funding Opportunity (NOFO) is to catalyze the development and testing of Artificial Intelligence (AI)-enabled, image-centered, multimodal Clinical Decision Support (CDS) tools, developed in pursuance as Software as a Medical Device (SaMD). These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.

Who can apply

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Topics and uses of funds

Topics

  • Health
  • Technology
  • Science

Program contact

National Institutes of HealthODPRIMED-AI@od.nih.gov301-402-2541

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